Key result
The cGMP-PKG pathway mediates anti-proliferative effects and increases smooth muscle-specific gene expression, though the exact mechanisms regulating vascular smooth muscle cell phenotype remain unknown.
Population
Vascular smooth muscle cells (cultured cells and in vivo animal models)
Design
Review
Authors
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Supports cGMP-PKG as potential anti-atherosclerotic target; leaves open exact mechanisms of VSMC phenotype regulation.
This review highlights the role of the cGMP-PKG pathway in regulating vascular smooth muscle cell phenotype and its potential anti-atherosclerotic effects.
Miguel Thomas (2006) conducted a review in Vascular smooth muscle cell phenotype regulation. cGMP and cGMP-dependent protein kinase (PKG) was evaluated. The cGMP-PKG pathway mediates anti-proliferative effects and increases smooth muscle-specific gene expression, though the exact mechanisms regulating vascular smooth muscle cell phenotype remain unknown.
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