cGMP Signaling and Vascular Smooth Muscle Cell Plasticity
Population
Cultured vascular smooth muscle cells and mouse models of atherosclerosis, restenosis, and angiogenesis
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
cGMP modulation of VSMC plasticity in atherosclerosis remains hypothesis-generating; leaves open targeted therapies pending mechanistic validation.
Structured PICO
P
Population
Cultured vascular smooth muscle cells (VSMCs) and mouse models of atherosclerosis, restenosis, and angiogenesis
I
Intervention
cGMP signaling (NO-cGMP-cGKI pathway)
O
Outcome
VSMC growth, survival, and phenotypic plasticity
This review challenges the traditional view by proposing that cGMP promotes, rather than inhibits, phenotypic switching and growth of vascular smooth muscle cells in atherosclerotic lesions.
Cite This Study
Lehners et al. (2018) studied this question.