March 8, 2002Circulation ResearchOpen Access

Sp1 Transcription Factor as a Molecular Target for Nitric Oxide– and Cyclic Nucleotide–Mediated Suppression of cGMP-Dependent Protein Kinase-Iα Expression in Vascular Smooth Muscle Cells

View Full Paper

Ask AI

Bookmark

Population

Cultured vascular smooth muscle cells (VSMCs) and A7r5 cells

Comparison

Exposure to nitric oxide donors and cyclic… vs Basal conditions

Design

Preclinical

Authors

HSHassan SellakEmory University XYXiangli YangUniversity College Dublin XCXu CaoCentral South University

Discussion

Member takes

Implication

Sp1 emerges as a regulator of vascular PKG-Ialpha; hypothesis-generating for human disease with no immediate clinical implications.

Structured PICO

Population

Cultured vascular smooth muscle cells (VSMCs) and A7r5 cells

Intervention

Exposure to nitric oxide (NO) donors and cyclic nucleotide analogues (cAMP, cGMP)

Comparator

Basal conditions

Outcome

PKG-Ialpha promoter activity and gene expressionsurrogate

This study identifies the Sp1 transcription factor as a key molecular target through which nitric oxide and cAMP suppress PKG-Ialpha expression in vascular smooth muscle cells.

Cite This Study

Sellak et al. (2002) studied this question.

synapsesocial.com/papers/6a7035a6febe604dd708fe9e https://doi.org/10.1161/hh0402.105898

View Full Paper

Ask AI

Bookmark

Sp1 Transcription Factor as a Molecular Target for Nitric Oxide– and Cyclic Nucleotide–Mediated Suppression of cGMP-Dependent Protein Kinase-Iα Expression in Vascular Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sp1 Transcription Factor as a Molecular Target for Nitric Oxide– and Cyclic Nucleotide–Mediated Suppression of cGMP-Dependent Protein Kinase-Iα Expression in Vascular Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider