Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 2002AJP Heart and Circulatory Physiology

ATP-sensitive K+channel activation by nitric oxide and protein kinase G in rabbit ventricular myocytes

View Full Paper
Ask AI
Bookmark
Share

Population

Rabbit ventricular myocytes

Comparison

Nitric oxide donors, cGMP analogs, and Protein… vs Control conditions

Design

Preclinical

Authors

JHJin HanNKNari KimHJHyun Joo

Discussion

Loading...

Member takes

Overview

Supports NO-cGMP-PKG activation of ventricular K(ATP) channels; leaves open clinical translation.

Structured PICO

P
Population
Rabbit ventricular myocytes
I
Intervention
Nitric oxide donors (Sodium nitroprusside 1 mM), cGMP analogs (8-pCPT-cGMP), and Protein Kinase G (PKG)
C
Comparator
Control conditions (heat-inactivated PKG, inside-out/outside-out patches, protein phosphatase 2A)
O
Outcome
ATP-sensitive K(+) (K(ATP)) channel activity measured by patch-clamp techniquessurrogate

This preclinical study demonstrates that the NO-cGMP-PKG pathway activates ATP-sensitive K+ channels via phosphorylation in rabbit ventricular myocytes.

Cite This Study

Han et al. (2002) studied this question.

synapsesocial.com/papers/6a7fb58ca3d55be9ef9fe8a3https://doi.org/10.1152/ajpheart.01052.2001
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial natriuretic factor and isosorbide dinitrate modulate the gating of ATP-sensitive K+ channels in cultured vascular smooth muscle cells.1994 · 159 citations
  2. 2Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning.1992 · 182 citations
  3. 3Effects of intracoronary cromakalim on postischaemic contractile function and action potential duration1992 · 60 citations
  4. 4Nitric oxide donor SIN-1 inhibits mammalian cardiac calcium current through cGMP-dependent protein kinase1995 · 215 citations
  5. 5Protection against autonomic denervation following acute myocardial infarction by preconditioning ischemia.1989 · 72 citations