Population
Isolated rabbit aorta (endothelium-denuded rings)
Design
Preclinical
Authors
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NO may stimulate vascular Na-K-ATPase independently of cGMP; leaves open relevance to human vascular tone or NO-based therapies.
Nitric oxide stimulates Na(+)-K(+)-ATPase activity in vascular smooth muscle through a cGMP-independent mechanism, likely secondary to increased Na(+)-H+ exchange.
Gupta et al. (1994) studied this question.
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