Short term regulation of endothelial Na+-K+-pump activity by cGMP: A133Cs magnetic resonance study

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Population

Porcine aortic endothelial cells (in vitro cell system)

Design

Preclinical

Authors

Discussion

Preclinical finding suggests NO-cGMP inhibition of endothelial Na-K-ATPase; leaves open relevance to human vascular or cardiac ion regulation.

Population

Porcine aortic endothelial cells (in vitro cell system)

Intervention

Nitric oxide radicals (NO), 8-Br-cGMP, and L-NAME

Outcome

Na(+)-K(+)-ATPase pump activitysurrogate

This preclinical study demonstrates that endogenous nitric oxide continuously regulates and reduces endothelial Na+-K+-pump activity via cGMP.

Gruwel et al. (1998) studied this question.

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Preclinical finding suggests NO-cGMP inhibition of endothelial Na-K-ATPase; leaves open relevance to human vascular or cardiac ion regulation.