Population
Rabbit aortic smooth muscle cells in primary culture and intact rabbit aorta rings
Comparison
Nitric oxide (10 - 10 M) with or without… vs Control conditions without inhibitors or lower…
Design
Preclinical
Authors
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High-dose NO may relax vascular smooth muscle via cGMP-independent paths; hypothesis-generating and leaves open human translation.
Nitric oxide induces smooth muscle relaxation and decreases intracellular calcium through both cyclic GMP-dependent and cyclic GMP-independent mechanisms.
Weisbrod et al. (1998) studied this question.
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