Key result
Stimulation of endogenous NO synthesis by lipopolysaccharide or low doses of nitroglycerine significantly increased Na+, K+-ATPase activity in rat aorta, whereas high doses inhibited the enzyme.
Population
White Wistar rats weighing 200-250 g
Comparison
Intraperitoneal injection of bacterial… vs Intraperitoneal injection of physiological saline
Design
Preclinical
Follow-up
30 minutes post-injection
Authors
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Should not yet alter clinical NO donor use; leaves open translation of dose-dependent ATPase effects to human vessels.
Effect estimate: 87.5% increase
Absolute Event Rate: 14.3% vs 7.6%
p-value: p=<0.01
Nitric oxide exerts a dose-dependent effect on Na+, K+-ATPase activity in rat aorta in vivo, with low doses activating and high doses inhibiting the enzyme via free-radical reactions.
Ov et al. (2009) studied Healthy (evaluating NO action on Na+, K+-ATPase). Nitric oxide stimulation (LPS and nitroglycerine) vs. Saline (control) was evaluated on Na+, K+-ATPase activity in rat aorta (micromol Pi/h per mg protein) (87.5% increase, p=<0.01). Stimulation of endogenous NO synthesis by lipopolysaccharide or low doses of nitroglycerine significantly increased Na+, K+-ATPase activity in rat aorta, whereas high doses inhibited the enzyme.
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