Key result
In isolated rat hearts, nitric oxide donors induced a positive inotropic response that was augmented 4-fold by the inhibition of endogenous NO synthase.
p-value: p=<0.05
Physiological NO concentrations support myocardial performance, and endogenous NO production appears to almost maximally exploit this positive inotropic effect in normal rat hearts.
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Hypothesis-generating for NO donors in contractility; leaves open clinical translation pending in vivo trials.
Müller‐Strahl et al. (2000) studied Normal saline-perfused rat hearts. Nitric oxide donors (GTN, SNAP, DEA/NO) and NO synthase inhibitor (L-NA) vs. Baseline / absence of L-NA was evaluated on Positive inotropic response (maximal rate of increase of left ventricular pressure, +dP/dtmax) (p=<0.05). In isolated rat hearts, nitric oxide donors induced a positive inotropic response that was augmented 4-fold by the inhibition of endogenous NO synthase.
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