Key result
Organic nitrates are bioactivated to NO in cardiac muscle, causing a moderate increase in cGMP that improves contractile response (141.6 +/- 6.4%) by activating cAMP-dependent protein kinase.
Population
Isolated adult rat ventricular cardiomyocytes and isolated rat papillary muscles
Comparison
Organic nitrates and spontaneous NO donors vs Control values
Design
Preclinical
Authors
Loading...
Hypothesis-generating for direct inotropic effects of organic nitrates; leaves open translation to human cardiac function.
In rat ventricular myocytes, organic nitrates are bioactivated to NO, causing a moderate increase in cGMP that improves contractile response via cAMP, whereas high NO doses reduce contractility.
Kojda et al. (1996) studied Healthy rat cardiomyocytes. Organic nitrates and spontaneous NO donors vs. Control was evaluated on Electrically stimulated contractile response (CR) and cAMP/cGMP content. Organic nitrates are bioactivated to NO in cardiac muscle, causing a moderate increase in cGMP that improves contractile response (141.6 +/- 6.4%) by activating cAMP-dependent protein kinase.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: