March 1, 1998British Journal of PharmacologyOpen Access

Effect of nitrovasodilators and inhibitors of nitric oxide synthase on ischaemic and reperfusion function of rat isolated hearts

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Why the study?

Does modulation of the NO/cyclic GMP pathway improve ischaemic and reperfusion function in rat isolated hearts?

Population

Rat isolated hearts subjected to experimental myocardial ischaemia (reducing coronary flow to 0.2 ml min for…

Comparison

Drugs inhibiting or stimulating the NO/cyclic… vs Vehicle-treated hearts (control).

Design

Preclinical

Follow-up

25 min baseline, 25 or 40 min ischaemia, 25 min reperfusion

Authors

ETEugene F. Du ToitGriffith University JMJoy McCarthyMemorial University of Newfoundland JMJody K. MiyashiroMaine Medical Center

Discussion

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Implication

May improve post-ischaemic recovery in isolated rat hearts; hypothesis-generating for NO/cGMP modulation, should not yet change practice.

Structured PICO

Does modulation of the NO/cyclic GMP pathway improve ischaemic and reperfusion function in rat isolated hearts?

Population

Rat isolated hearts subjected to experimental myocardial ischaemia (reducing coronary flow to 0.2 ml min(-1) for 25 or 40 min) and reperfusion (25 min).

Intervention

Drugs inhibiting or stimulating the NO/cyclic GMP pathway (nitroprusside, N(G)-nitro-L-arginine [L-NOARG], dobutamine, Sp-8-pCPT-cGMPS) infused during the ischaemic phase only.

Comparator

Vehicle-treated hearts (control).

Outcome

Ischaemic contracture, myocardial cyclic GMP and cyclic AMP levels during ischaemia, and recovery of reperfusion mechanical function (left ventricular developed pressure [LVDevP]).surrogate

The cardioprotective effect of NO donors in ischaemia-reperfusion may be mediated by elevated cyclic GMP levels, whereas the benefits of low-dose NO synthase inhibitors appear independent of reduced NO and peroxynitrite formation.

Cite This Study

Toit et al. (1998) studied this question.

synapsesocial.com/papers/6a83a67c6eaad3b729ee7775 https://doi.org/10.1038/sj.bjp.0701694

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Effect of nitrovasodilators and inhibitors of nitric oxide synthase on ischaemic and reperfusion function of rat isolated hearts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of nitrovasodilators and inhibitors of nitric oxide synthase on ischaemic and reperfusion function of rat isolated hearts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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