Key result
Administration of physiological concentrations of exogenous nitric oxide does not acutely depress the inotropic state of isolated rat or cat cardiac muscle to a physiologically significant extent.
Why the study?
Do physiological concentrations of exogenous nitric oxide elicit an acute negative inotropic effect in isolated cat and rat cardiac muscle?
Do physiological concentrations of exogenous nitric oxide elicit an acute negative inotropic effect in isolated cat and rat cardiac muscle?
Physiological concentrations of exogenous nitric oxide do not elicit an acute negative inotropic effect in unstimulated cardiac muscle.
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Physiological NO lacks acute negative inotropic effects in isolated cardiac muscle; leaves open translation to in vivo or human myocardium.
Weyrich et al. (1994) studied Isolated cardiac muscle contractility. Nitric oxide donors, authentic NO gas, and L-arginine vs. Unstimulated state or D-arginine was evaluated on Inotropic effect / contractile force. Administration of physiological concentrations of exogenous nitric oxide does not acutely depress the inotropic state of isolated rat or cat cardiac muscle to a physiologically significant extent.
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