Key result
In guinea-pig atrial myocytes, phenylephrine enhanced the slow component of delayed rectifier K+ current by up to 97.1%, an effect predominantly mediated by the PKC epsilon isoform.
Population
Guinea-pig atrial myocytes
Comparison
Phenylephrine, PKC inhibitors… vs Control conditions
Design
Preclinical
Authors
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Should not alter alpha1-agonist use; leaves open PKC epsilon as IKs modulator in human atria.
In guinea-pig atrial myocytes, activation of the PKCepsilon isoform predominantly contributes to alpha1-adrenoceptor-mediated potentiation of the slow delayed rectifier K+ current (I(Ks)).
Toda et al. (2007) studied this question. Phenylephrine was evaluated on I (Ks) potentiation. In guinea-pig atrial myocytes, phenylephrine enhanced the slow component of delayed rectifier K+ current by up to 97.1%, an effect predominantly mediated by the PKC epsilon isoform.
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