Why the study?
Does acetylcholine affect electromechanical characteristics in guinea-pig atria and ventricles?
Population
Guinea-pig atria and ventricles (isolated myocardium and isolated cardiac cells)
Design
Preclinical
Authors
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Highlights species-specific cholinergic responses in guinea-pig myocardium; leaves open translation to human atrial and ventricular function.
Does acetylcholine affect electromechanical characteristics in guinea-pig atria and ventricles?
Acetylcholine exerts direct negative inotropic effects and shortens action potential duration in both atrial and ventricular guinea-pig myocardium, with greater sensitivity in atria.
Zang et al. (2004) studied this question.
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