Population
Rat ventricular (n=11) and atrial (n=4) myocytes
Comparison
Acetylcholine exposure at concentrations ranging… vs Baseline contraction/action potential or…
Design
Preclinical
Follow-up
3 minutes
Authors
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ACh reduces ventricular contraction less than atrial; extends cellular data but leaves open human translation.
Acetylcholine directly decreases contraction in rat ventricular myocytes by shortening action potential duration through K+ current activation, though the effect is less pronounced than in atrial cells.
McMorn et al. (1993) studied this question.
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