Population
Human right atrial strips and isolated working rat hearts (including rat ventricular strips)
Comparison
Acetylcholine exposure, with or without… vs Baseline/control conditions, and antagonism with…
Design
Preclinical
Authors
Loading...
Should not change clinical practice; leaves open positive inotropic cholinergic effects for further mechanistic study.
Contrary to the generally known negative inotropic effects, cholinergic muscarinic stimulation with acetylcholine can produce positive inotropic effects in human and rat cardiac muscle, potentially mediated by IP3.
Nadler et al. (1993) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: