Key result
Changes in alpha-adrenergic and M-cholinergic responses in the heart depend on underlying causes, with altered receptor sensitivities observed in animal models and human failing myocardium.
Population
Heart muscle preparations from cardiomyopathic hamsters, human failing myocardium, and rat models
Design
Review
Authors
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HF etiology may shape alpha-adrenergic and muscarinic responses; leaves open etiology-specific trials before clinical adoption.
Changes in alpha-adrenergic and M-cholinergic responses in the heart are dependent on the specific underlying pathophysiological causes.
Schmitz et al. (1991) conducted a review in Heart failure / Idiopathic dilated cardiomyopathy. Alpha-adrenergic and M-cholinergic agonists was evaluated. Changes in alpha-adrenergic and M-cholinergic responses in the heart depend on underlying causes, with altered receptor sensitivities observed in animal models and human failing myocardium.
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