Why the study?
Does alpha-1 adrenoceptor stimulation with phenylephrine decrease isometric tension in mouse myocardium through PKC activation?
Population
Isolated ventricular papillary muscles of C57BL/6 strain mice
Comparison
Phenylephrine with or without prazosin… vs Baseline/control conditions
Design
Preclinical
Authors
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Highlights species differences in myocardial alpha-1 signaling; leaves open PKC-mediated Ca2+ desensitization in human hearts.
Does alpha-1 adrenoceptor stimulation with phenylephrine decrease isometric tension in mouse myocardium through PKC activation?
The negative inotropic effect of alpha-1 adrenoceptor stimulation in mouse myocardium is mediated by decreased Ca2+ sensitivity through PKC activation, highlighting important species differences in cardiac physiology.
Hirano et al. (2006) studied this question.
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