Why the study?
Does alpha(1B)-AR overexpression alter the inotropic response to phenylephrine in the mouse myocardium?
Population
Systemically expressing mouse model that overexpresses the alpha-adrenergic receptor and isolated adult…
Comparison
Phenylephrine-induced conditions in alpha-AR… vs Age-matched normal mice
Design
Preclinical
Authors
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Alpha(1B)-AR overexpression may blunt alpha(1A)-mediated inotropy in mice; hypothesis-generating for receptor subtype interactions without clinical implications.
Does alpha(1B)-AR overexpression alter the inotropic response to phenylephrine in the mouse myocardium?
The alpha(1B)-adrenergic receptor does not play a major role in positive inotropy in the mouse myocardium but may negatively modulate the alpha(1A)-AR response.
Seamus Ross (2003) studied this question.
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