Why the study?
Does alpha1-adrenergic receptor deletion worsen the cardiac response to pressure overload in mice?
Population
Mice with double knockout of the 2 main alpha1-adrenergic receptor subtypes in the heart, alpha 1A and alpha…
Comparison
Transverse aortic constriction to induce cardiac… vs Wild-type mice undergoing transverse aortic…
Design
Preclinical
Follow-up
2 weeks
Authors
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Alpha1-adrenergic receptor knockout impairs adaptation to pressure overload in mice; hypothesis-generating for alpha1-antagonist risks in clinical heart failure.
Does alpha1-adrenergic receptor deletion worsen the cardiac response to pressure overload in mice?
Alpha1-adrenergic receptor signaling is required for cardiac adaptation to pressure overload, providing a mechanistic explanation for the adverse heart failure outcomes observed with alpha1-antagonists in clinical trials.
Timothy D. O’Connell (2006) studied this question.
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