January 1, 2001AJP Heart and Circulatory Physiology

α-Adrenoceptor stimulation-mediated negative inotropism and enhanced Na+/Ca2+exchange in mouse ventricle

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Population

Adult mouse ventricular myocardium (isolated ventricular tissue and whole cell voltage-clamped myocytes)

Comparison

Phenylephrine (PE) in the presence of propranolol vs Basal conditions and various ion channel/pump…

Design

Preclinical

Authors

KNKazuhide NishimaruYamagata University MKMay KobayashiToho University TMTomoyuki MatsudaChiba University

Discussion

Member takes

Implication

NCX mediates alpha-adrenergic negative inotropy in adult mouse myocardium; leaves open translation to human cardiac effects or therapy.

Structured PICO

Population

Adult mouse ventricular myocardium (isolated ventricular tissue and whole cell voltage-clamped myocytes)

Intervention

Phenylephrine (PE) in the presence of propranolol

Comparator

Basal conditions and various ion channel/pump inhibitors (nicardipine, ryanodine, ouabain, dimethylamiloride, KB-R7943)

Outcome

Contractile force and ion currents (L-type Ca2+, Na+/Ca2+ exchanger, K+, Na+-K+-pump)surrogate

The sustained negative inotropic response to alpha-adrenoceptor stimulation in adult mouse ventricular myocardium is mediated by enhanced Ca2+ efflux through the Na+/Ca2+ exchanger.

Cite This Study

Nishimaru et al. (2001) studied this question.

synapsesocial.com/papers/6a75e71c49d3dc94b07860f7 https://doi.org/10.1152/ajpheart.2001.280.1.h132

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α-Adrenoceptor stimulation-mediated negative inotropism and enhanced Na+/Ca2+exchange in mouse ventricle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

α-Adrenoceptor stimulation-mediated negative inotropism and enhanced Na+/Ca2+exchange in mouse ventricle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider