Why the study?
Does phenylephrine stimulate Na-K pump current via alpha 1b-adrenoceptors in adult rat ventricular myocytes?
Population
Single adult rat ventricular myocytes isolated by enzymatic disaggregation
Comparison
Phenylephrine at various doses in the presence… vs Baseline holding current or response in the…
Design
Preclinical
Authors
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Hypothesis-generating in rat myocytes; leaves open alpha1b targeting for human Na-K pump modulation.
Does phenylephrine stimulate Na-K pump current via alpha 1b-adrenoceptors in adult rat ventricular myocytes?
The alpha 1-adrenoceptor-mediated increase in Na-K pump current in isolated rat ventricular myocytes is driven specifically by the stimulation of alpha 1b-adrenergic receptors.
Williamson et al. (1993) studied this question.
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