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November 1, 1988Proceedings of the National Academy of SciencesOpen Access

Alpha 1-adrenergic agonists selectively suppress voltage-dependent K+ current in rat ventricular myocytes.

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Key result

Alpha 1-adrenergic agonists (phenylephrine and methoxamine) prolonged action-potential durations and selectively suppressed voltage-dependent K+ current in adult rat ventricular myocytes.

Population

Isolated adult rat ventricular myocytes

Comparison

Alpha 1-adrenergic agonists applied via puffer vs Baseline/absence of agonists

Design

Preclinical

Authors

MAMichael ApkonUniversity of TorontoJNJeanne M. NerbonneElectrophysiology

Discussion

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Implication

Hypothesis-generating in rat myocytes; leaves open translation to human ventricular electrophysiology or therapy.

Structured PICO

P
Population
Isolated adult rat ventricular myocytes
I
Intervention
Alpha 1-adrenergic agonists (phenylephrine 5-20 microM or methoxamine 5-10 microM) applied via puffer
C
Comparator
Baseline/absence of agonists
O
Outcome
Waveforms of action potentials and voltage-gated ionic currents (specifically Ca2+-independent voltage-activated outward K+ currents, Iout)surrogate

Activation of alpha 1-adrenergic receptors in adult rat ventricular myocytes prolongs action potentials by specifically suppressing outward K+ currents, likely mediated by protein kinase C.

Cite This Study

Apkon et al. (1988) studied Isolated adult rat ventricular myocytes. Alpha 1-adrenergic agonists (phenylephrine and methoxamine) was evaluated on Waveforms of action potentials and voltage-gated ionic currents. Alpha 1-adrenergic agonists (phenylephrine and methoxamine) prolonged action-potential durations and selectively suppressed voltage-dependent K+ current in adult rat ventricular myocytes.

synapsesocial.com/papers/6a0cfa6eb31ab1d6e01e73dehttps://doi.org/10.1073/pnas.85.22.8756
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early outward current in rat single ventricular cells.1984 · 321 citations
  2. 2Intracellular Ca2+ and protein kinase C modulate K+ current in guinea pig heart cells1987 · 138 citations
  3. 3Effects of α‐adrenoceptor stimulation with phenylephrine in the presence of propranolol on force of contraction, slow inward current and cyclic AMP content in the bovine heart1984 · 126 citations
  4. 4Phorbol esters mimic some cholinergic actions in hippocampal pyramidal neurons1986 · 215 citations
  5. 5Kinase C activator 1,2-oleoylacetylglycerol attenuates voltage-dependent calcium current in sensory neurons.1986 · 313 citations