Alpha‐adrenergic modulation of the transient outward current in rabbit atrial myocytes.
Population
Rabbit atrial myocytes
Comparison
Alpha-adrenergic agonists vs Baseline/control conditions without…
Design
Preclinical
Authors
Discussion
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Implication
Alpha-adrenergic effects on Ito in rabbit myocytes warrant no clinical extrapolation; leaves open relevance to human atrial electrophysiology.
Structured PICO
P
Population
Rabbit atrial myocytes
I
Intervention
Alpha-adrenergic agonists (noradrenaline, methoxamine, phenylephrine)
C
Comparator
Baseline/control conditions without alpha-adrenergic agonists
O
Outcome
Action potential duration and membrane currents (specifically transient outward current, It)surrogate
Alpha-adrenergic agonists prolong action potential duration in rabbit atrial myocytes primarily by reducing the transient outward current.
Cite This Study
Fedida et al. (1990) studied this question.