Key result
The WB-4101 sensitive alpha 1-adrenoceptor subtype mediates positive inotropism correlated with APD prolongation, whereas the CEC-sensitive subtype mediates inotropism associated with increased myofibrillar Ca2+ sensitivity.
Population
Rat and rabbit ventricular myocardium (papillary muscles and ventricular cells)
Design
Preclinical
Authors
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Subtype-specific inotropic mechanisms in animal myocardium warrant targeted follow-up; leaves open translation to human HF therapy.
Different alpha 1-adrenoceptor subtypes mediate distinct inotropic and electrophysiological mechanisms in mammalian myocardium, with WB-4101-sensitive receptors linked to APD prolongation and CEC-sensitive receptors to increased Ca2+ sensitivity.
Nagashima et al. (1996) studied this question. Alpha 1-adrenoceptor stimulation (phenylephrine, WB-4101, CEC) was evaluated on Inotropic and electrophysiological effects (APD prolongation, Ito reduction). The WB-4101 sensitive alpha 1-adrenoceptor subtype mediates positive inotropism correlated with APD prolongation, whereas the CEC-sensitive subtype mediates inotropism associated with increased myofibrillar Ca2+ sensitivity.
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