Population
Rabbit ventricular muscle/myocardium
Comparison
BMY 7378 at concentrations ranging from 1 nM to… vs Phenylephrine alone or in combination with other…
Design
Preclinical
Authors
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Supports α1D-adrenoceptor role in rabbit contractility; leaves open human therapeutic relevance.
BMY 7378 demonstrates biphasic antagonistic action on phenylephrine-induced positive inotropic effects, suggesting alpha 1D-adrenoceptors contribute to regulating myocardial contractility in rabbit ventricular muscle.
Yang et al. (1997) studied this question.
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