Population
Adult rat ventricular myocytes
Comparison
Phenylephrine in the presence of 1 microM… vs Conventional whole cell voltage-clamp techniques
Design
Preclinical
Authors
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Requires perforated-patch methods to capture full alpha1 effects on ICa,L; leaves open translation to intact cardiomyocyte physiology.
Alpha1-adrenergic stimulation enhances cardiac L-type Ca2+ current, an effect that requires intracellular mediators which are preserved in perforated-patch but lost in conventional whole-cell recordings.
Liu et al. (1998) studied this question.
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