Cholinergic mechanisms on the heart and coronary circulation

Q: What does this research mean for the field?

Acetylcholine affects the heart and coronary circulation by inducing coronary dilation, a negative inotropic response, and a slow positive inotropic response via muscarinic receptors, while also triggering a fast positive inotropic response mediated by catecholamine release. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Marta I. Blesa; Gordon Ross

doi:10.1111/j.1476-5381.1970.tb10339.x

January 1, 1970British Journal of PharmacologyOpen Access

Cholinergic mechanisms on the heart and coronary circulation

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Structured PICO

P

Population

anaesthetized open chest dogs

I

Intervention

rapid intracoronary injection of acetylcholine (ACh) in increasing doses from 0.01 to 100 mug

O

Outcome

Changes in phasic coronary blood flow and contractile forcesurrogate

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Implication

In a canine model, acetylcholine induces coronary vasodilation and complex inotropic responses mediated by muscarinic receptors and catecholamine release.

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Blesa et al. (1970) studied this question.

synapsesocial.com/papers/6a1564b015658026c0824b81 https://doi.org/10.1111/j.1476-5381.1970.tb10339.x

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Cholinergic mechanisms on the heart and coronary circulation

Structured PICO

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Implication

Abstract

Discussion

Cite This Study

Cholinergic mechanisms on the heart and coronary circulation

Structured PICO

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Implication

Abstract

Discussion

Cite This Study

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