March 1, 1998AJP Regulatory Integrative and Comparative Physiology

Atrial natriuretic peptide and mechanisms of cardiovascular control. Role of serotonergic receptors

View Full Paper

Ask AI

Bookmark

Population

Anesthetized, sinoaortically denervated rats (n=9 in one group)

Comparison

Intravenous ANP or intrapericardial ANP in the… vs Absence of 5-HT3 antagonist or alternative route…

Design

Preclinical

Authors

RDRobin DelivaHospital for Sick Children UAUwe AckermannAustin Health

Discussion

Member takes

Implication

Supports 5-HT3 mediation of ANP sympathoinhibition outside epicardial sites in animals; leaves open human translation.

Structured PICO

Population

Anesthetized, sinoaortically denervated rats (n=9 in one group)

Intervention

Intravenous ANP (100 or 200 ng) or intrapericardial ANP (100 or 1,000 ng) in the presence or absence of 5-HT3 antagonist (Ondansetron, 20 micrograms/kg)

Comparator

Absence of 5-HT3 antagonist or alternative route of administration

Outcome

Changes in arterial blood pressure (ABP), heart rate, and renal sympathetic nerve activity (RSNA)surrogate

The sympathoinhibitory effects of ANP are mediated by a 5-HT3 agonist mechanism that is not localized to epicardial chemosensitive afferents.

Cite This Study

Deliva et al. (1998) studied this question.

synapsesocial.com/papers/6a7609d5554f5a6e3e613abb https://doi.org/10.1152/ajpregu.1998.274.3.r711

View Full Paper

Ask AI

Bookmark