March 1, 1989Circulation ResearchOpen Access

Pressor hormones regulate atrial-stretch-induced release of atrial natriuretic peptide in the pithed rat.

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Population

Conscious rats and pithed rats

Comparison

Acute volume expansion by 0.9% saline with or… vs Basal conditions, conscious rats, or pithed rats…

Design

Preclinical

Authors

HRHeikki RuskoahoHeart Failure & Transplant OVOlli VakkuriUniversity of Oulu OAOlli ArjamaaUniversity of Turku

Discussion

Member takes

Implication

May indicate vasopressin requirement for ANP release in rats; leaves open relevance to human volume regulation.

Structured PICO

Population

Conscious rats and pithed rats

Intervention

Acute volume expansion by 0.9% saline (4 ml) with or without infusion of pressor hormones (vasopressin, epinephrine, angiotensin), brain extracts, or autonomic nerve stimulation

Comparator

Basal conditions, conscious rats, or pithed rats without hormone infusion

Outcome

Plasma immunoreactive ANP (IR-ANP) concentrationssurrogate

Pressor hormones, particularly vasopressin, are required to permit normal atrial-stretch-induced release of atrial natriuretic peptide in vivo.

Cite This Study

Ruskoaho et al. (1989) studied this question.

synapsesocial.com/papers/6a20b8719e00afa23b234aea https://doi.org/10.1161/01.res.64.3.482

View Full Paper

Ask AI

Bookmark

Pressor hormones regulate atrial-stretch-induced release of atrial natriuretic peptide in the pithed rat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pressor hormones regulate atrial-stretch-induced release of atrial natriuretic peptide in the pithed rat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider