Key result
Acute blood volume expansion increases circulating ANP ~2-3x in rats via neural and pituitary pathways.
Why the study?
Mechanisms regulating the release of atrial natriuretic peptides (ANP) from cardiac atria are poorly understood, particularly the role of humoral influences from the anterior pituitary gland.
Does the anterior pituitary gland modulate the release of atrial natriuretic peptides in response to acute volume loading in rats?
Population
Rats with indwelling catheters including intact, pithed, hypophysectomized, and anterior pituitary reimplanted
Comparison
Basal state versus acute blood volume expansion with 5% dextrose across different surgical states
Design
Preclinical experimental study with surgical interventions
Authors
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No immediate clinical implications for volume management; leaves open pituitary modulation of ANP secretion in humans.
Does the anterior pituitary gland modulate the release of atrial natriuretic peptides in response to acute volume loading in rats?
Effect estimate: increased by a factor of 2-3
Hormones of anterior pituitary origin are required for atrial natriuretic peptide secretion in response to acute volume loading in rats.
Zamir et al. (1987) studied this question. Acute blood volume expansion, pithing, and hypophysectomy with or without anterior pituitary reimplantation vs. Basal state or hypophysectomized state was evaluated on Circulating immunoreactive ANP (increased by a factor of 2-3). Acute blood volume expansion increased circulating ANP by a factor of 2-3 in rats, an effect blocked by pithing and blunted by hypophysectomy but restored by anterior pituitary reimplantation.
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