Key result
Blockade of muscarinic cholinergic or alpha-adrenergic receptors in the AV3V region markedly suppressed the 3-fold increase in plasma ANP induced by blood volume expansion in conscious rats.
Population
Conscious rats
Comparison
Microinjection of receptor-blocking drugs into… vs Microinjection of isotonic saline into the AV3V…
Design
Preclinical
Follow-up
35 minutes (5 minutes post-volume expansion)
Authors
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Identifies AV3V muscarinic/alpha-adrenergic control of ANP in rats; leaves open translation to human volume homeostasis or therapy.
Hypothalamic muscarinic and alpha-adrenergic synapses are essential for the release of atrial natriuretic peptide in response to blood volume expansion.
Antunes‐Rodrigues et al. (1993) studied this question. Receptor-blocking drugs (atropine sulfate, methylatropine, phentolamine) injected into the AV3V region vs. Isotonic saline (2 microliters) into AV3V region was evaluated on Plasma ANP concentrations. Blockade of muscarinic cholinergic or alpha-adrenergic receptors in the AV3V region markedly suppressed the 3-fold increase in plasma ANP induced by blood volume expansion in conscious rats.
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