Minimal N-methylated and stapled peptide inhibitors of the autophagy protein GABARAP

Key Points

• The study focuses on developing inhibitors for GABARAP to selectively target autophagy processes.
• Developed minimal n-methylated and stapled peptides targeting GABARAP.
• Evaluated peptide efficacy in inhibiting autophagy pathways in vitro.
• Demonstrated significant inhibition of autophagy with peptides in cell models.
• Peptides showed a higher binding affinity to GABARAP compared to non-modified counterparts.