Minimal N-methylated and stapled peptide inhibitors of the autophagy protein GABARAP

I. McDonald; Joana Alessandra Wilms; Nicholas Cardi; Alexander Engstrom; Joshua Kritzer; Jiayuan Miao; Dieter Willbold; Yu-Shan Lin; R. Scott Lokey; Oliver H. Weiergraeber

doi:10.1039/d6cb00111d

January 1, 2026RSC Chemical BiologyOpen Access

Minimal N-methylated and stapled peptide inhibitors of the autophagy protein GABARAP

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Key Points

The study focuses on developing inhibitors for GABARAP to selectively target autophagy processes.
Developed minimal n-methylated and stapled peptides targeting GABARAP.
Evaluated peptide efficacy in inhibiting autophagy pathways in vitro.
Demonstrated significant inhibition of autophagy with peptides in cell models.
Peptides showed a higher binding affinity to GABARAP compared to non-modified counterparts.

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Implication

Investigates GABARAP inhibition effects in autophagy, suggesting therapeutic potential.

Abstract

The LC3/GABARAP protein family is a promising target for selective inhibition of autophagy. Further, LC3/GABARAP ligands have been used as targeted degraders of soluble proteins, protein aggregates, mitochondria, lipid droplets,...

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Cite This Study

McDonald et al. (2026) studied this question.

synapsesocial.com/papers/6a17dc653fad632b0f9d90cd https://doi.org/10.1039/d6cb00111d

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Minimal N-methylated and stapled peptide inhibitors of the autophagy protein GABARAP

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Minimal N-methylated and stapled peptide inhibitors of the autophagy protein GABARAP

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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