What question did this study set out to answer?

To develop a catalyst-free method for the O2-mediated alkylation of azauracils using alkylboronic acids.

May 28, 2026Advanced Synthesis & Catalysis0 citations

Catalyst‐Free, O 2 ‐Mediated C(sp 2 )H Alkylation of Azauracils With Alkylboronic Acids

TQTaorui QuChangzhou University YGYanmei GongChangzhou University JYJin‐Tao YuChangzhou University

Key Points

To develop a catalyst-free method for the O2-mediated alkylation of azauracils using alkylboronic acids.
Utilized O2 as the sole oxidant in the reaction.
Conducted reactions under mild conditions without catalysts.
Achieved high yields of alkylated azauracils with good substrate scope.
Achieved yields up to 90% for C6-alkylated azauracils.
Demonstrated broad functional group tolerance.
Successful reaction without the need for catalysts.

Abstract

The O 2 ‐mediated radical alkylation of azauracils via the autoxidation of alkylboronic acids was developed under mild reaction conditions. In this transformation, O 2 was employed as sole oxidant to access a variety of C6‐alkylated azauracils in yields up to 90% under catalyst‐free conditions. This reaction features with broad substrate scope, good functional group tolerance and easy operation.

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