Catalyst-free alkylation improves yield of C6-alkylated azauracils, suggesting a new mild oxidation method.
The O 2 ‐mediated radical alkylation of azauracils via the autoxidation of alkylboronic acids was developed under mild reaction conditions. In this transformation, O 2 was employed as sole oxidant to access a variety of C6‐alkylated azauracils in yields up to 90% under catalyst‐free conditions. This reaction features with broad substrate scope, good functional group tolerance and easy operation.
No takes yet. Share an insight, caveat, or question.
Qu et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: