Catalyst‐Free, O 2 ‐Mediated C(sp 2 )H Alkylation of Azauracils With Alkylboronic Acids

Key Points

• To develop a catalyst-free method for the O2-mediated alkylation of azauracils using alkylboronic acids.
• Utilized O2 as the sole oxidant in the reaction.
• Conducted reactions under mild conditions without catalysts.
• Achieved high yields of alkylated azauracils with good substrate scope.
• Achieved yields up to 90% for C6-alkylated azauracils.
• Demonstrated broad functional group tolerance.
• Successful reaction without the need for catalysts.