AHRE duration ≥24 hours was associated with a significantly higher incidence of MACEs compared to <24 hours in patients without a history of AF (92% vs. 30%, p=0.005).
Observational (n=132)
No
Does AHRE duration ≥24 h predict MACEs in CIED-implanted patients with and without a history of atrial fibrillation?
Long-duration AHRE (≥24 h) independently predicts major adverse cardiovascular events in CIED patients without a history of atrial fibrillation, but not in those with prior AF.
Absolute Event Rate: 92% vs 30%
p-value: p=0.005
Long-duration atrial high-rate episodes (AHREs) monitored using cardiac implantable electronic devices (CIEDs) can predict long-term major adverse cardiovascular events (MACEs). This study aimed to compare the impact of long-duration AHRE on MACE development between patients with and without a history of atrial fibrillation (AF). This single-center observational study included 132 CIED-implanted patients with AHREs detected via remote monitoring. The population was dichotomized into groups: with (n = 69) and without (n = 63) AF. In each group, cumulative incidences of MACEs comprising all-cause deaths, heart failure hospitalizations, strokes, and acute coronary syndromes were compared between patients with AHRE durations of ≥24 h and <24 h. Multivariate analysis was performed to identify predictors of MACEs among patients without AF. MACE incidence was significantly higher in patients with AHRE ≥24 h than in those with <24 h in the group without AF (92% vs. 30%, p = 0.005). MACE incidence did not significantly differ between AHRE ≥24 h and <24 h in the group with AF (54% vs. 26%, p = 0.44). After a multivariate adjustment, AHRE duration of ≥24 h emerged as the only independent predictor of MACEs among patients without AF (p = 0.03). In conclusion, a long-duration AHRE was prognostic in patients without a history of AF but not in patients with a history of AHREs.
Ishiguchi et al. (Mon,) conducted a observational in Atrial high-rate episodes (AHREs) in CIED-implanted patients (n=132). AHRE duration ≥24 h vs. AHRE duration <24 h was evaluated on MACEs comprising all-cause deaths, heart failure hospitalizations, strokes, and acute coronary syndromes (p=0.005). AHRE duration ≥24 hours was associated with a significantly higher incidence of MACEs compared to <24 hours in patients without a history of AF (92% vs. 30%, p=0.005).
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