Why the study?
Reversal treatment is commonly used for oral anticoagulant-associated intracranial haemorrhages, but its effects on mortality remain understudied, particularly across various subtypes of intracranial haemorrhage.
Does contemporary reversal treatment reduce mortality in patients with oral anticoagulant-associated acute intracranial haemorrhages compared to no reversal treatment?
Population
Patients with oral anticoagulant-associated acute intracranial haemorrhage
Comparison
Contemporary reversal treatment vs no reversal treatment
Design
Protocol for a systematic review and meta-analysis
Authors
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Will address reversal mortality benefit in OAC-ICH; planned Level 1 synthesis will clarify practice and research priorities.
Does contemporary reversal treatment reduce mortality in patients with oral anticoagulant-associated acute intracranial haemorrhages compared to no reversal treatment?
This is a protocol for a planned systematic review and meta-analysis to evaluate the impact of reversal therapies on mortality in patients with OAC-associated intracranial hemorrhage.
Tallroth et al. (2025) studied this question.
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