Higher HbA1c levels were significantly associated with the presence of carotid artery plaques (8.10% vs 7.12%, P=0.008) in patients with ischemic stroke.
Cross-Sectional (n=92)
Single-blind
No
Does HbA1c level associate with carotid atherosclerosis (CIMT and plaque) in ischemic stroke patients?
Higher HbA1c levels are significantly associated with the presence of carotid plaques in ischemic stroke patients, suggesting its utility as a marker for advanced atherosclerosis.
Absolute Event Rate: 8.103% vs 7.122%
p-value: p=0.008
CONTEXT: Glycated hemoglobin A1c(HbA1c) indicates long-term uncontrolled hyperglycemia in the body, which in diabetic patients leads to various vascular complications as a part of generalized atherosclerosis culminating ultimately into ischemic stroke. AIMS: Study aims to show the association between marker of uncontrolled long-term hyperglycemia HbA1c and marker of atherosclerosis (Carotid intima media thickness CIMT and carotid plaque) in ischemic stroke patients. SUBJECTS AND METHODS: Carotid sonography using high resolution 7.5 MHz sonography technique was done in each patient to find the occurrence of increased CIMT and presence of plaque according to Mannheim CIMT Consensus (2004-2006). Levels of HbA1c measured in blood in both diabetic and non-diabetic patients and a comparison made between them. Finally an association sought between HbA1c levels with CIMT and plaque. RESULTS: The average value of HbA1c of this cohort was 7.51 ± 1.75% with higher values in diabetic patients (9.29 ± 1.73%). The patients with high CIMT (>0.8 mm) had higher values of HbA1c then that of normal CIMT patients and this was nearly significantly (P = 0.06). However, HbA1c levels of blood were significantly associated with stroke patients with presence of carotid arteries plaque (P = 0.008). CONCLUSIONS: Prediction of future risk and prevention strategies for ischemic stroke could be formulated by utilizing HbA1c levels in both diabetic and non-diabetic population.
Singh et al. (2013) conducted a cross-sectional in Ischemic stroke (n=92). HbA1c levels vs. Patients without carotid plaque was evaluated on Association of HbA1c levels with the presence of carotid artery plaque (p=0.008). Higher HbA1c levels were significantly associated with the presence of carotid artery plaques (8.10% vs 7.12%, P=0.008) in patients with ischemic stroke.