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November 1, 1986HeartOpen Access

Long term improvement in global left ventricular function after early thrombolytic treatment in acute myocardial infarction. Report of a randomised multicentre trial of intracoronary streptokinase in acute myocardial infarction.

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Why the study?

Does early intracoronary streptokinase improve global left ventricular ejection fraction in patients with acute myocardial infarction?

Population

533 patients with acute myocardial infarction

Comparison

Early intracoronary streptokinase vs Conventional treatment

Design

RCT, randomised

Follow-up

three months

Authors

JCJ CMSMaarten L. SimoonsEWErnst E. van der Wall

Discussion

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Member takes

Overview

Supports early intracoronary streptokinase for LVEF preservation in acute MI; confirms benefit in this RCT.

Structured PICO

Does early intracoronary streptokinase improve global left ventricular ejection fraction in patients with acute myocardial infarction?

P
Population
533 patients with acute myocardial infarction
I
Intervention
Early intracoronary streptokinase
C
Comparator
Conventional treatment
O
Outcome
Global left ventricular ejection fraction determined by radionuclide angiography at two days, two weeks, and three monthssurrogate

Early intracoronary streptokinase significantly improves long-term global left ventricular ejection fraction in patients with acute myocardial infarction compared to conventional treatment.

Limitations

  • Photon attenuation within the body limited the assessment of differences in patients with inferior myocardial infarction

Cite This Study

C et al. (1986) studied this question.

synapsesocial.com/papers/6a1d125cdabf5784132f3179https://doi.org/10.1136/hrt.56.5.414
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