Demonstrates the existence of a humoral factor ('Thrombopoietin') that regulates platelet production and suggests a feedback mechanism involving viable platelets.
SUMMARY Plasma from thrombocytopenic animals induces thrombocytosis in normal recipients. Thrombocytopenia induced by platelet antiserum or bleeding is followed by a reactive thrombocytosis and animals in this phase of increased platelet count provide a more sensitive system for the demonstration of ‘Thronibopoietin’. This humoral factor may be inactivated or removed by viable platelets suggesting the mode of operation of the thrombopoietic ‘feed‐back’ mechanism.
Gabriele et al. (Wed,) studied this question.