Demonstrates the existence of a humoral factor ('Thrombopoietin') that regulates platelet production and suggests a feedback mechanism involving viable platelets.
Animal plasma data support a humoral thrombopoietic regulator; leaves open its identity and translation to human thrombocytopenia.
SUMMARY Plasma from thrombocytopenic animals induces thrombocytosis in normal recipients. Thrombocytopenia induced by platelet antiserum or bleeding is followed by a reactive thrombocytosis and animals in this phase of increased platelet count provide a more sensitive system for the demonstration of ‘Thronibopoietin’. This humoral factor may be inactivated or removed by viable platelets suggesting the mode of operation of the thrombopoietic ‘feed‐back’ mechanism.
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Gabriele et al. (1967) studied this question.
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