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January 1, 2000Thrombosis and Haemostasis

Platelets Release Thrombopoietin (Tpo) upon Activation: another Regulatory Loop in Thrombocytopoiesis?

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Population

Platelets (in vitro) and patients with disseminated intravascular coagulation (DIC)

Design

Preclinical

Authors

CFClaudia C. FolmanGLGabor E. LinthorstJMJan van Mourik

Discussion

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Overview

May implicate platelets as Tpo reservoir in DIC; hypothesis-generating for thrombocytopoiesis, needs prospective validation.

Structured PICO

P
Population
Platelets (in vitro) and patients with disseminated intravascular coagulation (DIC)
I
Intervention
Platelet stimulation with various agonists, Tpo-peptide mimetic, or truncated Tpo
O
Outcome
Tpo release and Tpo concentrationsurrogate

Platelets can function as a storage pool for Tpo and release it upon activation, which may stimulate thrombocytopoiesis in conditions with massive platelet activation like DIC.

Cite This Study

Folman et al. (2000) studied this question.

synapsesocial.com/papers/6a71384bfebe604dd709ebdchttps://doi.org/10.1055/s-0037-1613944
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Thrombopoietin is synergistic with other hematopoietic growth factors and physiologic platelet agonists for platelet activation in vitro1997 · 38 citations
  2. 2High-Level Expression of Mpl in Platelets and Megakaryocytes Is Independent of Thrombopoietin1999 · 18 citations
  3. 3Characterization of Native Human Thrombopoietin in the Blood of Normal Individuals and of Patients with Haematologic Disorders1999 · 11 citations
  4. 4The Diagnostic Value of Thrombopoietin Level Measurements in Thrombocytopenia1998 · 97 citations
  5. 5A sensitive sandwich ELISA for measuring thrombopoietin in human serum: serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders1996 · 208 citations