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September 1, 1998Stem CellsOpen Access

Native Thrombopoietin: Structure and Function

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Population

Normal individuals, thrombocytopenic patients, and thrombocytopenic animals

Design

Review

Authors

TKTakashi KatoVascular MedicineAMAtsushi MatsumotoUniversity of FukuiKOKinya OgamiKirin (Japan)

Discussion

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Implication

Challenges extrapolation of animal TPO truncation to humans; leaves open primary regulators of platelet production in patients.

Structured PICO

P
Population
Normal individuals, thrombocytopenic patients, and thrombocytopenic animals
O
Outcome
Characterization of Thrombopoietin (TPO) forms (full-length vs truncated) in plasmasurrogate

Full-length TPO is the predominant form in human blood, suggesting that truncation does not directly regulate platelet production in response to increased demand in humans, despite its presence in animal models.

Cite This Study

Kato et al. (1998) studied this question.

synapsesocial.com/papers/6a8bce7798aeeda2ff892e7dhttps://doi.org/10.1002/stem.160322
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Localization and Regulation of Thrombopoietin mRNA Expression in Human Kidney, Liver, Bone Marrow, and Spleen Using In Situ Hybridization1997 · 292 citations
  2. 2Characterization of the Human Thrombopoietin Gene Promoter1997 · 60 citations
  3. 3Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors1995 · 159 citations
  4. 4Human Platelets as a Model for the Binding and Degradation of Thrombopoietin1997 · 145 citations
  5. 5Multilineage Hematopoietic Recovery by a Single Injection of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor in Myelosuppressed Mice1998 · 63 citations