Population
Human polymorphonuclear cells (PMN) isolated from venous blood of healthy donors
Comparison
Thrombopoietin at concentrations ranging from… vs Vehicle alone or untreated cells
Design
Preclinical
Authors
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May implicate TPO in neutrophil inflammation beyond thrombopoiesis; leaves open human translation from animal data.
TPO may have an important role in regulating PMN activation and inflammation, extending its known functions beyond megakaryocytopoiesis.
Brizzi et al. (1997) studied this question.
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