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May 1, 1998Stem CellsOpen Access

Native thrombopoietin: Structure and function

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Population

Normal individuals, thrombocytopenic patients, and thrombocytopenic animals

Design

Review

Authors

TKTakashi KatoVascular MedicineAMAtsushi MatsumotoUniversity of FukuiKOKinya OgamiKirin (Japan)

Discussion

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Implication

Challenges assumptions on TPO truncation; leaves open primary mechanisms regulating platelet production in thrombocytopenia.

Structured PICO

P
Population
Normal individuals, thrombocytopenic patients, and thrombocytopenic animals

The study clarifies that circulating thrombopoietin is predominantly full-length in humans, indicating that proteolytic truncation in the blood is not the primary mechanism for regulating platelet production during increased demand.

Cite This Study

Kato et al. (1998) studied this question.

synapsesocial.com/papers/6a8bce7798aeeda2ff892e7ehttps://doi.org/10.1002/stem.5530160704
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Activity of the ligand for c‐mpl, thrombopoietin, in early haemopoiesis1996 · 32 citations
  2. 2Thrombin cleaves recombinant human thrombopoietin: One of the proteolytic events that generates truncated forms of thrombopoietin1997 · 36 citations
  3. 3Characterization of the Human Thrombopoietin Gene Promoter1997 · 60 citations
  4. 4Biological Roles for the Second Domain of Thrombopoietin1996 · 20 citations
  5. 5Identification of Functionally Important Residues of Human Thrombopoietin1998 · 31 citations