Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 1, 1999BloodOpen Access

TPO does not have a major effect on the transcription or translation of Mpl, but excess circulating TPO can lead to the disappearance of Mpl from platelets via catabolism.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does Thrombopoietin (TPO) regulate the expression of its receptor Mpl in megakaryocytes and platelets?

Population

In vitro megakaryocytes and in vivo mouse models

Comparison

Presence of Thrombopoietin in vitro or ectopic… vs Absence of TPO in vitro, normal mice, or TPO…

Design

Preclinical

Authors

KCKarine Cohen-SolalRutgers, The State University of New JerseyNVNatacha VitratAmgen (United States)MTMonique TiteuxCentre National de la Recherche Scientifique

Discussion

Loading...

Member takes

Overview

Animal data on TPO-driven Mpl catabolism remain preclinical; leaves open human relevance for platelet disorders.

Structured PICO

Does Thrombopoietin (TPO) regulate the expression of its receptor Mpl in megakaryocytes and platelets?

P
Population
In vitro megakaryocytes and in vivo mouse models (normal, TPO knockout, mildly TPO-stimulated, and severely thrombocythemic mice)
I
Intervention
Presence of Thrombopoietin (TPO) in vitro or ectopic secretion of TPO in vivo
C
Comparator
Absence of TPO in vitro, normal mice, or TPO knockout mice
O
Outcome
Expression levels of Mpl (c-mpl transcripts and protein levels)surrogate

This study demonstrates that while TPO does not regulate Mpl transcription or translation, excess TPO causes Mpl catabolism in platelets, providing insight into TPO receptor regulation.

Cite This Study

Cohen-Solal et al. (1999) studied this question.

synapsesocial.com/papers/6a8a41960f137e402b337b44https://doi.org/10.1182/blood.v93.9.2859
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serum Thrombopoietin and cMpl Expression in Thrombocytopenia of Different Etiologies2014 · 10 citations
  2. 2Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease2024 · 3 citations
  3. 3Hematopoietic Deficiencies in c‐mpl and TPO Knockout Mice1998 · 127 citations
  4. 4Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit1996 · 40 citations
  5. 5Thrombopoietin1999 · 15 citations