Key result
Thrombocytopenic states are linked to ~264% higher serum thrombopoietin and increased platelet cMpl expression versus controls.
Why the study?
The relationship between thrombopoietin and its receptor cMpl in thrombocytopenic conditions has not been entirely clarified.
Population
43 patients with thrombocytopenia due to ITP, bone marrow hypoplasia, MDS, and familial thrombocytopenia
Comparison
Patients with normal platelet count and patients with thrombocytosis due to essential thrombocythemia
Design
Observational study
Authors
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No immediate change to thrombocytopenia management; leaves open TPO/cMpl axis as therapeutic target in ITP and MDS.
Observational (n=75)
No
Absolute Event Rate: 160% vs 44%
p-value: p=<0.001
Thrombocytopenic states are associated with increased platelet cMpl expression and generally higher TPO levels compared to healthy controls.
Vianello et al. (2014) conducted an observational in Thrombocytopenia of different etiologies (n=75). Thrombocytopenic conditions (e.g., ITP, MDS, bone marrow hypoplasia) vs. Healthy controls was evaluated on Serum thrombopoietin (TPO) levels (pg/mL) in ITP patients vs controls (p=<0.001). Thrombocytopenic states including ITP, MDS, and bone marrow hypoplasia were associated with significantly increased serum thrombopoietin levels and platelet cMpl expression compared to healthy controls.
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