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January 1, 1998Stem CellsOpen Access

Both TPO and c-mpl knockout mice have a 90% reduction in platelet counts caused by a reduction in progenitor cell numbers and a decrease in Meg ploidy.

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Population

c-mpl and TPO knockout mice

Design

Preclinical

Authors

MMMaximilien MuroneDCDavid A. CarpenterFSFrédéric J. de Sauvage

Discussion

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Overview

TPO/c-mpl knockout data establish its primacy in megakaryocyte progenitor expansion; leaves open translation to human platelet disorders.

Structured PICO

P
Population
c-mpl and TPO knockout mice
I
Intervention
Disruption of TPO or c-mpl genes
O
Outcome
Platelet counts, megakaryocyte ploidy, and progenitor cell numberssurrogate

TPO and its receptor c-mpl primarily control the number of megakaryocytes and platelets rather than their maturation, and circulating TPO levels are regulated by platelet mass.

Cite This Study

Murone et al. (1998) studied this question.

synapsesocial.com/papers/6a715c91f44fa9f079df282fhttps://doi.org/10.1002/stem.160001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin1998 · 389 citations
  2. 2Regulation of hematopoietic stem cells by their mature progeny2010 · 69 citations
  3. 3High-Level Expression of Mpl in Platelets and Megakaryocytes Is Independent of Thrombopoietin1999 · 18 citations
  4. 4Thrombopoietin1999 · 15 citations
  5. 5Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling2017 · 4 citations