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January 1, 1999Thrombosis and Haemostasis

Thrombopoietin: From Theory to Reality

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Key result

This review discusses the physiology of thrombopoietin production and function to explain platelet homeostasis and improve care for thrombocytopenic patients.

Population

Thrombocytopenic patients

Design

Review

Authors

KKK KaushanskyUniversity of Washington

Discussion

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Member takes

Implication

Clarifies TPO physiology for platelet homeostasis; extends knowledge but leaves open optimal translation to thrombocytopenia care.

Structured PICO

P
Population
Thrombocytopenic patients
E
Exposure
Thrombopoietin (TPO)

This review summarizes the physiology of thrombopoietin production and function, and its translation into clinical care for thrombocytopenic patients.

Cite This Study

K Kaushansky (1999) conducted a review in Thrombocytopenia. Thrombopoietin was evaluated. This review discusses the physiology of thrombopoietin production and function to explain platelet homeostasis and improve care for thrombocytopenic patients.

synapsesocial.com/papers/6ab33b265e64c1e80fb39a98https://doi.org/10.1055/s-0037-1615848
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Murine thrombopoietin mRNA levels are modulated by platelet count1995 · 200 citations
  2. 2Circulating thrombopoietin level in chronic immune thrombocytopenic purpura1996 · 222 citations
  3. 3The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit1995 · 397 citations
  4. 4Serum thrombopoietin levels in patients with aplastic anaemia1996 · 112 citations
  5. 5Chromosome 3q21 abnormalities associated with hyperactive thrombopoiesis in acute blastic transformation of chronic myeloid leukemia1986 · 83 citations